Special Section on Bio-MEMS and Microfluidics

Design, fabrication, and packaging of a practical multianalyte-capable optical biosensor

[+] Author Affiliations
D. A. Chang-Yen

University of Utah, Department of Mechanical Engineering, Salt Lake City, Utah 84112

B. K. Gale

University of Utah, Department of Mechanical Engineering, Salt Lake City, Utah 84112

J. Micro/Nanolith. MEMS MOEMS. 5(2), 021105 (May 23, 2006). doi:10.1117/1.2203666
History: Received August 26, 2005; Revised March 27, 2006; Accepted April 03, 2006; Published May 23, 2006
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A unique evanescent-wave biosensor was designed and fabricated using simple and robust microfabrication technology. The sensor uses a microscale optical waveguide fabricated from NOA61 that is surface-altered with a custom chemical modification process, coupled with modified self-assembly of an oxygen-sensitive fluorescent dye and the enzyme glucose oxidase. To interface the analyte with the waveguide surface, a multilayer PDMS fluidic mold was designed to fit over the waveguide. Interfacing of both optics and fluidics was achieved using novel-generic methods. The entire device has been successfully fabricated and assembled, with analyte response testing completed using glucose solutions. The system also demonstrated inherent random noise insensitivity while making measurements.

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© 2006 Society of Photo-Optical Instrumentation Engineers

Citation

D. A. Chang-Yen and B. K. Gale
"Design, fabrication, and packaging of a practical multianalyte-capable optical biosensor", J. Micro/Nanolith. MEMS MOEMS. 5(2), 021105 (May 23, 2006). ; http://dx.doi.org/10.1117/1.2203666


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