Design, fabrication, and packaging of a practical multianalyte-capable optical biosensor

David A. Chang-Yen; Bruce K. Gale

doi:10.1117/1.2203666

1 April 2006 Design, fabrication, and packaging of a practical multianalyte-capable optical biosensor

David A. Chang-Yen, Bruce K. Gale

Journal of Micro/Nanolithography, MEMS, and MOEMS, Vol. 5, Issue 2, 021105 (April 2006). https://doi.org/10.1117/1.2203666

Abstract

A unique evanescent-wave biosensor was designed and fabricated using simple and robust microfabrication technology. The sensor uses a microscale optical waveguide fabricated from NOA61 that is surface-altered with a custom chemical modification process, coupled with modified self-assembly of an oxygen-sensitive fluorescent dye and the enzyme glucose oxidase. To interface the analyte with the waveguide surface, a multilayer PDMS fluidic mold was designed to fit over the waveguide. Interfacing of both optics and fluidics was achieved using novel-generic methods. The entire device has been successfully fabricated and assembled, with analyte response testing completed using glucose solutions. The system also demonstrated inherent random noise insensitivity while making measurements.

©(2006) Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation Download Citation

David A. Chang-Yen and Bruce K. Gale "Design, fabrication, and packaging of a practical multianalyte-capable optical biosensor," Journal of Micro/Nanolithography, MEMS, and MOEMS 5(2), 021105 (1 April 2006). https://doi.org/10.1117/1.2203666

Published: 1 April 2006

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available