A novel thermoelectric cooling/heating device was proposed and fabricated as an alternative to the conventional -type device. The novel device is the first since the conventional -type structure was fabricated a half-century ago. The structure includes a sharp tip that is positioned between p- and n-type bulks, and the tip can easily be exchanged when different targets are cooled or heated. The tip sizes are when a copper tip is used and when a cantilever is used. The tip temperature reached during cooling and during heating. Our device is useful not only for cooling/heating micro-objects but also for heat manipulation of micro-organisms.