We examine the necessary technologies to be mastered in order to build a practical microarray-based immunoassay cassette and its processing station for protein analysis. The interdependence of surface chemistry, dye stability, and imaging are outlined, showing why a treated film of nitrocellulose adhered by an intervening layer to glass offers an efficacious surface for immobilizing an array of protein probes. The properties of a storage surface to support in desiccated form, fluidize and transport additional reagents are outlined, and a practical solution proposed. Wet and dry imaging are compared. The steps and functions expected for an assay platform comprising a processing station and biochip cassette are identified. The performance of a successful benchtop automated multiplex immunoassay system is briefly described.