Articles

Prevention of nonspecific adsorption onto a poly(dimethylsiloxane) microchannel in a microsensor chip by using a self-assembled monolayer

[+] Author Affiliations
Toshikazu Kawaguchi

Art, Science and Technology Center for Cooperative Research, Kasuga-shi, Fukuoka, 816-8580, Japan

Hiroyuki Iwasaka

Omron Corporation, Core Technology Center, Kizugawa-shi, Kyoto, 619-0283, Japan

Kiyoshi Matsumoto

Kyushu University, Graduate School of Agriculture, Fukuoka, 812-8581, Japan

Kiyoshi Toko

Kyushu University, Graduate School of Information Science and Electrical Engineering, Fukuoka, 819-0395, Japan

Norio Miura

Art, Science and Technology Center for Cooperative Research, Kasuga-shi, Fukuoka, 816-8580, Japan

J. Micro/Nanolith. MEMS MOEMS. 9(1), 013012 (March 22, 2010). doi:10.1117/1.3366559
History: Received September 30, 2009; Revised January 31, 2010; Accepted February 04, 2010; Published March 22, 2010; Online March 22, 2010
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Poly (dimethylsiloxane) (PDMS) is meant to be utilized for a miniaturized sensor system. However, protein and biospecies often adsorb onto a PDMS surface nonspecifically. This matter is a serious challenge in the study of miniaturized sensor systems. We provide the solution, which is a prevention technique of nonspecific adsorption onto a PDMS microchip by using a functionalized silane compound self-assembled monolayer. Two demonstrations for bacteria and explosives were examined by atomic force microscopy and x-ray photoelectron spectroscopy. It was found that 1H, 1H, 2H, 2H-Perfluorooctyltriethoxysilane self-assembled monolayer on PDMS effectively blocked the nonspecific adsorption of Escherichia coli (O157:H7) and explosives such as 2, 4, 6-trinitrotoluene and 1, 3, 5-trinitroperhydro-1,3,5-triazine (RDX, Research Department Explosive).

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Toshikazu Kawaguchi ; Hiroyuki Iwasaka ; Kiyoshi Matsumoto ; Kiyoshi Toko and Norio Miura
"Prevention of nonspecific adsorption onto a poly(dimethylsiloxane) microchannel in a microsensor chip by using a self-assembled monolayer", J. Micro/Nanolith. MEMS MOEMS. 9(1), 013012 (March 22, 2010). ; http://dx.doi.org/10.1117/1.3366559


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