Special Section on BioMEMS, Theory and Practice of MEMS/NEMS, and Sensors

Cross-sectional shape effect for enhanced Raman spectroscopy on polymer-based microstructures

[+] Author Affiliations
Shaw-Hwa Parng

Industrial Technology Research Institute, Medical Electronics and Device Technology Center, Hsinchu, Taiwan, 310

Philip Drake

Industrial Technology Research Institute, Medical Electronics and Device Technology Center, Hsinchu, Taiwan, 310

Hong-Wen Chang

Industrial Technology Research Institute, Medical Electronics and Device Technology Center, Hsinchu, Taiwan, 310

Yuh-Jiuan Lin

Industrial Technology Research Institute, Medical Electronics and Device Technology Center, Hsinchu, Taiwan, 310

J. Micro/Nanolith. MEMS MOEMS. 9(3), 031002 (July 02, 2010). doi:10.1117/1.3432487
History: Received January 04, 2010; Revised April 04, 2010; Accepted April 12, 2010; Published July 02, 2010; Online July 02, 2010
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We prepare various polymer-based microstructures for gold colloid detection in a Raman system. Several surface treatment techniques as well as chip configurations are discussed with an emphasis on their strengths and limitations. First, the optimum focus space is found for the experiment. Next, surface treatment effects for the Raman signal on the polymer-based substrate are compared. Finally, the Raman intensity of three channel configurations is compared along the cross sectional direction. There results demonstrate that a triangle shape provides the highest intensity for the same microstructure depth. A signal-enhanced mechanism on the difference cross sectional surface is also discussed in this research. Optimal shape designs based on polymer-based configurations are proposed for Raman detection in microchannels. This can give rise to several interesting applications, including trapping viruses from samples, and enzymatic reaction from enzymatic immuno-assay systems for real-time monitoring.

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Shaw-Hwa Parng ; Philip Drake ; Hong-Wen Chang and Yuh-Jiuan Lin
"Cross-sectional shape effect for enhanced Raman spectroscopy on polymer-based microstructures", J. Micro/Nanolith. MEMS MOEMS. 9(3), 031002 (July 02, 2010). ; http://dx.doi.org/10.1117/1.3432487


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