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Microcarrier-controlled-microfluidic chip for microsphere single-pass applications by hot embossing lithography

[+] Author Affiliations
Ruixia Yang, Huaibo Qu

Hebei University of Technology, School of Information, No. 8 Guangrongdao, Hongqiao District, Tianjin, 300130, China

Peng Gao

Tianjin University, School of Electronic and Information Engineering, Tianjin, 300072, China

Hanmin Tian

Hebei University of Technology, School of Information, No. 8 Guangrongdao, Hongqiao District, Tianjin, 300130, China

J. Micro/Nanolith. MEMS MOEMS. 9(4), 043009 (December 07, 2010). doi:10.1117/1.3514710
History: Received May 06, 2010; Revised September 28, 2010; Accepted October 04, 2010; Published December 07, 2010; January 03, 2011
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The design and fabrication of a poly(dimethyl-siloxane) (PDMS)-based microfluidic device for microsphere single-pass applications are presented. The fabrication process includes the use of high-throughput hot embossing lithography (HEL) technology for the definition of the microchannels and standard cast molding process. The sealing of the Pyrex cover and the PDMS substrate is achieved using thermal bonding. The chip, including 20-μm microchannels for microsphere single-passing is already realized, and the fact that the size of the microchannels can be altered makes it convenient to be further optimized. Such single-pass separation of microspheres is very useful for the detection and counting of microspheres. As a new method, the design and fabrication of a microcarrier-controlled microfluidic device described here can be applied to flow cytometric systems for automated, integrated, and ultrafast bioassays and screenings.

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Ruixia Yang ; Huaibo Qu ; Peng Gao and Hanmin Tian
"Microcarrier-controlled-microfluidic chip for microsphere single-pass applications by hot embossing lithography", J. Micro/Nanolith. MEMS MOEMS. 9(4), 043009 (December 07, 2010). ; http://dx.doi.org/10.1117/1.3514710


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