Flexible electronic bands for the dynamic optical spectroscopic assessment of systemic lupus erythematosus in finger joints

Youngwan Kim; Alessandro Marone; George Danias; Kayla E. Neville; Andrea T. Frantz; Teja Kapoor; Laura Geraldino-Pardilla; Hyun K. Kim; Anca D. Askanase; Ioannis Kymissis; Andreas H. Hielscher

doi:10.1117/12.2510305

20 February 2019 Flexible electronic bands for the dynamic optical spectroscopic assessment of systemic lupus erythematosus in finger joints

Youngwan Kim, Alessandro Marone, George Danias, Kayla E. Neville, Andrea T. Frantz, Teja Kapoor, Laura Geraldino-Pardilla, Hyun K. Kim, Anca D. Askanase, Ioannis Kymissis, Andreas H. Hielscher

Author Affiliations +

Proceedings Volume 10885, Optical Diagnostics and Sensing XIX: Toward Point-of-Care Diagnostics; 108850Z (2019) https://doi.org/10.1117/12.2510305
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

We have developed a system of flexible optical imaging bands that can be used to assess the effects of systemic lupus erythematosus (SLE) on finger joints. Each imaging band consists of four pairs of light sources and a photodetector. The light sources contain three different light emitting diodes with wavelengths of 530 nm, 655 nm and 940 nm. Two of these imaging bands are wrapped around the proximal interphalangeal (PIP) joints of the index-, middle-, and ringfingers. The imaging bands gather transmitted and reflected light intensities from the tissues for ~ 4 minutes including two venous occlusions. This results in hemodynamic time traces for all source-detector pairs. From theses traces a rise, plateau, and fall time are calculated. We found that, on average, signals obtained from SLE patients displayed a shorter rise time and longer plateau time as compared to signals from healthy controls. Performing a two-dimensional linear discriminant analysis on the rise and plateau times, we obtained the best specificity of 89% and the best sensitivity of 76 %. Area under the receiver operating characteristic (ROC) curve is 0.86.

Citation Download Citation

Youngwan Kim, Alessandro Marone, George Danias, Kayla E. Neville, Andrea T. Frantz, Teja Kapoor, Laura Geraldino-Pardilla, Hyun K. Kim, Anca D. Askanase, Ioannis Kymissis, and Andreas H. Hielscher "Flexible electronic bands for the dynamic optical spectroscopic assessment of systemic lupus erythematosus in finger joints", Proc. SPIE 10885, Optical Diagnostics and Sensing XIX: Toward Point-of-Care Diagnostics, 108850Z (20 February 2019); https://doi.org/10.1117/12.2510305

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available