Endo-microscopic optical coherence tomography (emOCT) with dynamic contrast

Hinnerk Schulz-Hildebrandt; Martin Ahrens; Michael Münter; Elisa Wilken; Tabea Kohlfärber; Cornelia Holzhausen; Peter König; Gereon Hüttmann

doi:10.1117/12.2575733

5 March 2021 Endo-microscopic optical coherence tomography (emOCT) with dynamic contrast

Hinnerk Schulz-Hildebrandt, Martin Ahrens, Michael Münter, Elisa Wilken, Tabea Kohlfärber, Cornelia Holzhausen, Peter König, Gereon Hüttmann

Author Affiliations +

Proceedings Volume 11620, Endoscopic Microscopy XVI; 116200C (2021) https://doi.org/10.1117/12.2575733
Event: SPIE BiOS, 2021, Online Only

Abstract

Here we present a forward-looking endoscope for dynamic microscopic OCT reaching a lateral resolution of 1.3 µm and 0.8 mm field of view. Since tissue motion degrades dynamic imaging, tissue was immobilized by suction. The endoscope was placed in a 4 mm stainless-steel sheath, which was connected to a vacuum pump. In mice, the endoscope can access various inner organs using open surgery or laparoscopy. The potential of the dynamic endo-microscopic OCT was demonstrated on relevant murine tissue such as liver, spleen and kidney. Otherwise invisible cellular and subcellular structures were imaged by dynamic mOCT with high contrast.

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Hinnerk Schulz-Hildebrandt, Martin Ahrens, Michael Münter, Elisa Wilken, Tabea Kohlfärber, Cornelia Holzhausen, Peter König, and Gereon Hüttmann "Endo-microscopic optical coherence tomography (emOCT) with dynamic contrast", Proc. SPIE 11620, Endoscopic Microscopy XVI, 116200C (5 March 2021); https://doi.org/10.1117/12.2575733

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