Stimulatory effects of laser wavelengths on proliferation and angiogenesis of colon cancer: in-vitro and in-vivo evaluations

Hyejin Kim; Yeongeun Kim; Hyun Wook Kang

doi:10.1117/12.2626057

11 January 2022 Stimulatory effects of laser wavelengths on proliferation and angiogenesis of colon cancer: in-vitro and in-vivo evaluations

Hyejin Kim, Yeongeun Kim, Hyun Wook Kang

Author Affiliations +

Proceedings Volume 12159, SPIE Advanced Biophotonics Conference (SPIE ABC 2021); 121590F (2022) https://doi.org/10.1117/12.2626057
Event: SPIE Advanced Biophotonics Conference (SPIE ABC 2021), 2021, Busan, Republic of Korea

Abstract

Photobiomodulation (PBM) has been investigated for stimulation biological processes including wound healing and pain recovery. Therefore, in this study, the effects of PBM under Blue light (BL), Visible (VIS), and NIR laser irradiations on prostate cancer cells were evaluated to establish safety margins. In in vitro and in vivo studies, BL showed upregulated expression of VEGF, HIF-1α, EGFR, and MMP-9. These results suggested that BL can stimulate cancer cell proliferation, angiogenesis, and hypoxia, leading to aggressive tumor growth. These outcomes can provide a safety margin for the response of PBM-related stimulation after laser treatment.

Citation Download Citation

Hyejin Kim, Yeongeun Kim, and Hyun Wook Kang "Stimulatory effects of laser wavelengths on proliferation and angiogenesis of colon cancer: in-vitro and in-vivo evaluations", Proc. SPIE 12159, SPIE Advanced Biophotonics Conference (SPIE ABC 2021), 121590F (11 January 2022); https://doi.org/10.1117/12.2626057

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