Study progress in regulating microglia in Alzheimer's disease

Mengyuan Liu

doi:10.1117/12.3012851

8 January 2024 Study progress in regulating microglia in Alzheimer's disease

Mengyuan Liu

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 1292407 (2024) https://doi.org/10.1117/12.3012851
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

Alzheimer’s disease is known as a rather complex neurodegenerative disease caused by a combination of multiple factors.Numerous theories have been put out as potential causes of Alzheimer’s illness development, including cholinergic insufficiency, tau protein hyperphosphorylation, amyloid beta toxicity, synaptic dysfunction, and neuroinflammation. Microglia play a crucial role in the immune system and are considered to be the culprits of neuroinflammation in neurodegenerative diseases. With the emergence of single-cell and imaging technologies, the ontogeny, heterogeneity, and function of microglia in health and disease have been clarified, and the question of how to preserve homeostatic microglial function for the medical treatment of neurodegenerative illness has emerged.It is common to characterize microglial activation in terms of two broad polarization states, but the interaction between these two subtypes of activated glial cells can be extremely intricate, and the distribution of phenotypes can alter as neurodegenerative disorders develop. To achieve the purpose of creating efficient treatments, a deeper comprehension of the functions of microglia in neurodegenerative disorders is necessary.This review seeks to summarize the research progress on the pathological mechanisms of microglia and reported therapeutic implications currently under clinical evaluation.The improvements of treatments of neurodegenerative diseases through "modulation of microglia activationprotection neurons" related pathways will be highlighted.Understanding microglial growth and aging may, ideally, present a possibility for elucidating the mechanisms underlying Alzheimer's disease and creating cutting-edge treatments, opening up new avenues and opportunities for the creation of drugs.

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Mengyuan Liu "Study progress in regulating microglia in Alzheimer's disease", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 1292407 (8 January 2024); https://doi.org/10.1117/12.3012851

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KEYWORDS

Polarization

Inflammation

Cell phenotyping

Neurological disorders

Alzheimer disease

Brain

Brain diseases

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