Quantitative analysis at the molecular level of laser/neural tissue interactions using a liposome model system

David L. VanderMeulen; Prabhakar Misra; Jason Michael; Kenneth G. Spears; Mustafa Khoka

doi:10.1117/12.44149

1 May 1991 Quantitative analysis at the molecular level of laser/neural tissue interactions using a liposome model system

David L. VanderMeulen, Prabhakar Misra, Jason Michael, Kenneth G. Spears, Mustafa Khoka

Author Affiliations +

Proceedings Volume 1428, Three-Dimensional Bioimaging Systems and Lasers in the Neurosciences; (1991) https://doi.org/10.1117/12.44149
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

The research has focused on understanding the effects of irradiating liposomes containing organic dyes with nanosecond and picosecond pulses at 532 nm from Nd:YAG lasers. Time-correlated photon counting and phase-resolved fluorescence spectroscopy techniques have been employed to obtain multicomponent fluorescence lifetimes for the dye-liposome system. A quantitative model based on the experimental data supports a photo-induced thermal mechanism for release of liposome contents.

Citation Download Citation

David L. VanderMeulen, Prabhakar Misra, Jason Michael, Kenneth G. Spears, and Mustafa Khoka "Quantitative analysis at the molecular level of laser/neural tissue interactions using a liposome model system", Proc. SPIE 1428, Three-Dimensional Bioimaging Systems and Lasers in the Neurosciences, (1 May 1991); https://doi.org/10.1117/12.44149

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