Development of laser-induced fluorescence detection to assay DNA damage

Minoti Sharma; Harold G. Freund

doi:10.1117/12.44251

1 July 1991 Development of laser-induced fluorescence detection to assay DNA damage

Minoti Sharma, Harold G. Freund

Proceedings Volume 1435, Optical Methods for Ultrasensitive Detection and Analysis: Techniques and Applications; (1991) https://doi.org/10.1117/12.44251
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

The demand to measure high dynamic range isotope ratios on small samples with resonance ionization mass spectrometry (RIMS) continues to increase. This paper discusses high ionization efficiency methods which can be applied to continuous wave (cw) RIMS to potentially achieve several tens of percent ionization efficiencies for certain elements. The primary technique under development to achieve this is an external laser cavity which can generate very high circulating laser powers.

Citation Download Citation

Minoti Sharma and Harold G. Freund "Development of laser-induced fluorescence detection to assay DNA damage", Proc. SPIE 1435, Optical Methods for Ultrasensitive Detection and Analysis: Techniques and Applications, (1 July 1991); https://doi.org/10.1117/12.44251

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