Studies of the mutagenic effects of styrene to man: conclusions for the surveillance of styrene-exposed workers

Roland Rothe; P. Schmidt; T. Grummt; H. J. Grummt; N. Kersten; Hans-Juergen Weigmann

doi:10.1117/12.140278

9 March 1993 Studies of the mutagenic effects of styrene to man: conclusions for the surveillance of styrene-exposed workers

Roland Rothe, P. Schmidt, T. Grummt, H. J. Grummt, N. Kersten, Hans-Juergen Weigmann

Author Affiliations +

Proceedings Volume 1716, International Conference on Monitoring of Toxic Chemicals and Biomarkers; (1993) https://doi.org/10.1117/12.140278
Event: Environmental Sensing '92, 1992, Berlin, Germany

Abstract

One hundred fifty-six styrene-exposed workers had a fourfold higher rate of chromosome aberrations in peripheral lymphocytes than the control persons. The parameters of clinical chemistry (liver, kidney, and blood) remained in the normal range. Further analyses of the data of this study revealed no connections of the degree of effects in clinical chemistry and the exposure level. But a connection exists to the duration of exposure (3 - 26 years): in the comparison of the mean values (all mean values within the normal range) significant differences were found between long-term exposed workers (more than ten years) and control persons. In the higher age groups (above 45 years) also the GAP-rate differences are more pronounced. Seventy percent of the TWA-values were found to be below 85 mg/m³; the arithmetic mean of the TWA-values 72,3 mg/m³. A health surveillance program to styrene-exposed workers is to be reviewed (clinical chemistry and genetic effects). Proposals concerning both problems are presented.

Citation Download Citation

Roland Rothe, P. Schmidt, T. Grummt, H. J. Grummt, N. Kersten, and Hans-Juergen Weigmann "Studies of the mutagenic effects of styrene to man: conclusions for the surveillance of styrene-exposed workers", Proc. SPIE 1716, International Conference on Monitoring of Toxic Chemicals and Biomarkers, (9 March 1993); https://doi.org/10.1117/12.140278

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