Surface plasmon resonance imaging of Au nanoparticle-modified DNA monolayers

Akira Yamaguchi; Masayuki Hayashida; Saulius Juodkazis; Yoichiro Hara; Shigeki Matsuo; Hiroaki Misawa

doi:10.1117/12.491216

21 June 2002 Surface plasmon resonance imaging of Au nanoparticle-modified DNA monolayers

Akira Yamaguchi, Masayuki Hayashida, Saulius Juodkazis, Yoichiro Hara, Shigeki Matsuo, Hiroaki Misawa

Proceedings Volume 4626, Biomedical Nanotechnology Architectures and Applications; (2002) https://doi.org/10.1117/12.491216
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

A probe DNA monolayer modified with Au nano-particles was prepared on an Au thin film and used for DNA hybridization detection by surface plasmon resonance (SPR) spectroscopy. This Au particle modified probe DNA monolayer resulted in about a 3.5 times larger SPR angle shift according to the hybridization reaction, compared to that found in a non-modified probe DNA monolayer. By comparison of the SPR image of the particle modified and nonmodified probe DNA monolayer, this modification method was shown to be useful in improving the SPR signal for the detection ofthe unlabelled DNA molecules.

Citation Download Citation

Akira Yamaguchi, Masayuki Hayashida, Saulius Juodkazis, Yoichiro Hara, Shigeki Matsuo, and Hiroaki Misawa "Surface plasmon resonance imaging of Au nanoparticle-modified DNA monolayers", Proc. SPIE 4626, Biomedical Nanotechnology Architectures and Applications, (21 June 2002); https://doi.org/10.1117/12.491216

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