Resonant grating biosensor platform design and fabrication

Valerie Brioude; Rachida Saoudi; Daniele Blanc; Stephanie Reynaud; Svetlen Tonchev; Nikolai M. Lyndin; James Molloy

doi:10.1117/12.513695

26 February 2004 Resonant grating biosensor platform design and fabrication

Valerie Brioude, Rachida Saoudi, Daniele Blanc, Stephanie Reynaud, Svetlen Tonchev, Nikolai M. Lyndin, James Molloy

Proceedings Volume 5252, Optical Fabrication, Testing, and Metrology; (2004) https://doi.org/10.1117/12.513695
Event: Optical Systems Design, 2003, St. Etienne, France

Abstract

Grating coupled evanescent wave slab waveguide biosensors are now well established about twenty years after they were demonstrated. They usually rely upon mode excitation from the substrate side, providing a means to measure the bioreaction at the waveguide surface through the monitoring of the conditions of mode excitation. A new readout principle will be presented whereby the incident beam undergoes a sharp and high reflection while being trapped into the biomaterial loaded grating waveguide. The high index metal oxide waveguide and the grating are designed so that the evanescent wave sensitivity is maximum and the conditions for resonant reflection are fulfilled for both polarizations close to normal incidence. Under these conditions, the grating corrugation cannot be located on both sides of the waveguide, as usually preferred, since the grating strength of the TM polarization would be too low. The corrugation must therefore be at the analyte side of the metal oxide layer ; this calls for a specific grating fabrication technology. The option retained for low cost manufacturing is that of wet etching of Ta₂O₅. This is quite a challenging problem since there is no wet etchant of high density Ta₂O₅ which does not dissolve standard photoresist, and since the isotropy of wet etching is likely to smooth out the required short period corrugation by underetching. This paper describes the rationale of the design of the reflection interrogation scheme and brings the experimental evidence of the effect obtained on wet etched sensor platforms.

Citation Download Citation

Valerie Brioude, Rachida Saoudi, Daniele Blanc, Stephanie Reynaud, Svetlen Tonchev, Nikolai M. Lyndin, and James Molloy "Resonant grating biosensor platform design and fabrication", Proc. SPIE 5252, Optical Fabrication, Testing, and Metrology, (26 February 2004); https://doi.org/10.1117/12.513695

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