Laser-induced human serum fluorescence and Raman spectroscopy detection of colon cancer

Xiaozhou Li; Junxiu Lin; Chunyu Wu; Rong Wang; Yongkai Li; Chunde Jia

doi:10.1117/12.546250

4 December 2003 Laser-induced human serum fluorescence and Raman spectroscopy detection of colon cancer

Xiaozhou Li, Junxiu Lin, Chunyu Wu, Rong Wang, Yongkai Li, Chunde Jia

Proceedings Volume 5255, Biomolecular Photonics and Multidimensional Microscopy; (2003) https://doi.org/10.1117/12.546250
Event: Biomolecular Photonics and Multidimensional Microscopy, 2003, Wuhan, China

Abstract

Laser-induced fluorescence and Raman spectroscopy of serum for diagnostic colon cancer was investigated in this paper. The difference to serum spectrum was discovered. Three Raman peaks were consistently observed from normal blood serum emission using 488.0 nm and 514.5 nm excitation of an Ar-ior laser. While no Raman peak or slight Raman peaks were detected from colon cancer's cases. In addition, the red shift of fluorescence peak and decrease of fluorescence intensity are founded after samples radiated by laser. 120 colon cancer cases are investigated in this paper. Through three parameters we obtained an accuracy of 82.5% compared to clinical diagnosis. These results have important reference values to explore the method of Raman spectrum and LIF for diagnosis of cancer.

Citation Download Citation

Xiaozhou Li, Junxiu Lin, Chunyu Wu, Rong Wang, Yongkai Li, and Chunde Jia "Laser-induced human serum fluorescence and Raman spectroscopy detection of colon cancer", Proc. SPIE 5255, Biomolecular Photonics and Multidimensional Microscopy, (4 December 2003); https://doi.org/10.1117/12.546250

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