Integrated optical glucose sensor fabricated using PDMS waveguides on a PDMS substrate

David A. Chang-Yen; Bruce K. Gale

doi:10.1117/12.530062

23 December 2003 Integrated optical glucose sensor fabricated using PDMS waveguides on a PDMS substrate

David A. Chang-Yen, Bruce K. Gale

Proceedings Volume 5345, Microfluidics, BioMEMS, and Medical Microsystems II; (2003) https://doi.org/10.1117/12.530062
Event: Micromachining and Microfabrication, 2004, San Jose, California, United States

Abstract

This paper describes the design and fabrication of an integrated optical glucose sensing system using the combination of the oxygen sensitive dye tris(2,2’-bipyridyl) dichlororuthenium(II) hexahydrate and glucose oxidase. Layer-by-layer self-assembly is used to immobilize the dye/enzyme system onto the surface of the waveguides. Changes in the enzyme/dye system as it interacts with the surrounding environment are monitored using end-face interaction with light injected into waveguides. The waveguides are thermally-defined monolithic polydimethlysiloxane (PDMS) waveguide system, fabricated on a PDMS substrate. The method of waveguide fabrication is a radical departure from conventional microscale waveguide systems, and offers unique opportunities for integration of this sensor into existing microfluidic systems.

Citation Download Citation

David A. Chang-Yen and Bruce K. Gale "Integrated optical glucose sensor fabricated using PDMS waveguides on a PDMS substrate", Proc. SPIE 5345, Microfluidics, BioMEMS, and Medical Microsystems II, (23 December 2003); https://doi.org/10.1117/12.530062

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