Mechanisms of tumor destruction caused by photodynamic therapy

Chuannong Zhou

doi:10.1117/12.639100

11 September 2006 Mechanisms of tumor destruction caused by photodynamic therapy

Chuannong Zhou

Proceedings Volume 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery; 596706 (2006) https://doi.org/10.1117/12.639100
Event: 2004 Shanghai international Conference on Laser Medicine and Surgery, 2004, Shanghai, China

Abstract

Photodynamic therapy is a relatively new treatment modality and is becoming widely accepted as a standard treatment of a variety of solid tumors. This includes palliative treatments for advanced or obstructive cancers in many organs as well as a curative treatment for some early cancers and pre-cancerous lesions. It has been approved by health authorities in a number of countries in America, Europe and Asia. PDT is a procedure requiring 3 elements: photosensitizer, light and oxygen. The typical technique involves an intravenous administration of a photosensitizing agent, which is preferentially accumulated or retained in tumor tissue, followed by irradiation of the tumor area with light of appropriate wavelength. In the presence of oxygen it generates highly reactive and cytotoxic molecular species, in particular, singlet oxygen (¹O₂), which may oxidize various bio-molecules and finally leading to cell death and tumor destruction. The most widely used photosensitizer in clinical treatment of cancers is Photofrin (porfimer sodium), and most widely used light sources are lasers of various types, in recent years preferentially, diode laser, which emits a red light of 630 nm wavelength.

Citation Download Citation

Chuannong Zhou "Mechanisms of tumor destruction caused by photodynamic therapy", Proc. SPIE 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery, 596706 (11 September 2006); https://doi.org/10.1117/12.639100

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available