Interstitial pH, pO<sub>2</sub>, and pCO<sub>2</sub> controlled by optical sensors

Francesco Baldini; Alessandro Bizzarri; Merima Cajlakovic; Ambra Giannetti; Christian Konrad; Andrea Mencaglia

doi:10.1117/12.632061

7 November 2005 Interstitial pH, pO₂, and pCO₂ controlled by optical sensors

Francesco Baldini, Alessandro Bizzarri, Merima Cajlakovic, Ambra Giannetti, Christian Konrad, Andrea Mencaglia

Proceedings Volume 5993, Advanced Environmental, Chemical, and Biological Sensing Technologies III; 599309 (2005) https://doi.org/10.1117/12.632061
Event: Optics East 2005, 2005, Boston, MA, United States

Abstract

The continuous monitoring of interstitial pH, pO₂ and pCO₂ contained in the adipose tissue of intensive care patients, is one of the objective of the four year European project CLINICIP (Closed Loop Insulin Infusion in Critically Ill Patients). A glass capillary on line with the microfluidic system, is the solid support onto which the appropriate chemistry is immobilised. The optical working principle applied for the detection of oxygen and carbon dioxide is the modulation of the fluorescence lifetime, whereas absorption modulation is the approach followed for the pH detection. On this basis, two different optoelectronic units were developed for the interrogation of the glass capillary, one for life-time measurements and the other for absorption measurements. Preliminary tests demonstrated a resolution of 0.03 pH units for pH; ≤ 0.55 mmHg for oxygen and ≤ 0.6 mmHg for carbon dioxide; and an accuracy of 0.07 pH units for pH; ≤ 1 mmHg for oxygen and ≤ 1.5 mmHg for carbon dioxide.

Citation Download Citation

Francesco Baldini, Alessandro Bizzarri, Merima Cajlakovic, Ambra Giannetti, Christian Konrad, and Andrea Mencaglia "Interstitial pH, pO₂, and pCO₂ controlled by optical sensors", Proc. SPIE 5993, Advanced Environmental, Chemical, and Biological Sensing Technologies III, 599309 (7 November 2005); https://doi.org/10.1117/12.632061

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