Packaged Au-PPy valves for drug delivery systems

Han-Kuan Anthony Tsai; Kuo-Sheng Ma; Jim Zoval; Lawrence Kulinsky; Marc J. Madou

doi:10.1117/12.658742

22 March 2006 Packaged Au-PPy valves for drug delivery systems

Han-Kuan Anthony Tsai, Kuo-Sheng Ma, Jim Zoval, Lawrence Kulinsky, Marc J. Madou

Proceedings Volume 6168, Smart Structures and Materials 2006: Electroactive Polymer Actuators and Devices (EAPAD); 61681E (2006) https://doi.org/10.1117/12.658742
Event: SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, 2006, San Diego, California, United States

Abstract

The most common methods for the drug delivery are swallowing pills or receiving injections. However, formulations that control the rate and period of medicine (i.e., time-release medications) are still problematic. The proposed implantable devices which include batteries, sensors, telemetry, valves, and drug storage reservoirs provide an alternative method for the responsive drug delivery system [1]. Using this device, drug concentration can be precisely controlled which enhances drug efficiency and decreases the side effects. In order to achieve responsive drug delivery, a reliable release valve has to be developed. Biocompatibility, low energy consumption, and minimized leakage are the main requirements for such release method. A bilayer structure composed of Au/PPy film is fabricated as a flap to control the release valve. Optimized potentiostatic control to synthesize polypyrrole (PPy) is presented. The release of miniaturize valve is tested and showed in this paper. A novel idea to simultaneously fabricate the device reservoirs as well as protective packaging is proposed in this paper. The solution of PDMS permeability problem is also mentioned in this article.

Citation Download Citation

Han-Kuan Anthony Tsai, Kuo-Sheng Ma, Jim Zoval, Lawrence Kulinsky, and Marc J. Madou "Packaged Au-PPy valves for drug delivery systems", Proc. SPIE 6168, Smart Structures and Materials 2006: Electroactive Polymer Actuators and Devices (EAPAD), 61681E (22 March 2006); https://doi.org/10.1117/12.658742

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