Mitochondria In Cancer Cells As Targets Of Photodynamic Therapy

Russell Hilf; Scott L. Gibson; Richard S. Murant; Toni L. Ceckler; Robert G. Bryant

doi:10.1117/12.942683

19 February 1988 Mitochondria In Cancer Cells As Targets Of Photodynamic Therapy

Russell Hilf, Scott L. Gibson, Richard S. Murant, Toni L. Ceckler, Robert G. Bryant

Proceedings Volume 0847, New Directions in Photodynamic Therapy; (1988) https://doi.org/10.1117/12.942683
Event: Cambridge Symposium on Optics in Medicine and Visual Image Processing, 1987, San Diego, CA, United States

Abstract

Encouraging results are being reported in treatment of cancer by photodynamic therapy, consisting of the administration of hematoporphyrin photosensitizers and subsequent illumination of the neoplastic lesion with visible light. Studies in our laboratory have peen directed towards defining cellular sites of action of these photosensitizers. Results obtained using a rodent mammary carcinoma in vitro and in vivo indicate that an important target of tumor photosensitization is the mitochondrion, effects that are manifested by inhibition of enzymes involved in electron transport and oxidative phosphorylation. These events in turn lead to a significant reduction in cellular ATP, which we suggest represents an early and important mechanism that contributes to the ensuing tumor cytotoxicity. Optimization of this mechanism could provide improved efficacy of treatment.

Citation Download Citation

Russell Hilf, Scott L. Gibson, Richard S. Murant, Toni L. Ceckler, and Robert G. Bryant "Mitochondria In Cancer Cells As Targets Of Photodynamic Therapy", Proc. SPIE 0847, New Directions in Photodynamic Therapy, (19 February 1988); https://doi.org/10.1117/12.942683

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