Adaptive focus for deep tissue using diffuse backscatter

Jeremy Kress; Kambiz Pourrezaei

doi:10.1117/12.2032525

26 February 2014 Adaptive focus for deep tissue using diffuse backscatter

Jeremy Kress, Kambiz Pourrezaei

Proceedings Volume 8941, Optical Interactions with Tissue and Cells XXV; and Terahertz for Biomedical Applications; 89410P (2014) https://doi.org/10.1117/12.2032525
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

A system integrating high density diffuse optical imaging with adaptive optics using MEMS for deep tissue interaction is presented. In this system, a laser source is scanned over a high density fiber bundle using Digital Micromirror Device (DMD) and channeled to a tissue phantom. Backscatter is then collected from the tissue phantom by a high density fiber array of different fiber type and channeled to CMOS sensor for image acquisition. Intensity focus is directly verified using a second CMOS sensor which measures intensity transmitted though the tissue phantom. A set of training patterns are displayed on the DMD and backscatter is numerically fit to the transmission intensity. After the training patterns are displayed, adaptive focus is performed using only the backscatter and fitting functions. Additionally, tissue reconstruction and prediction of interference focusing by photoacoustic and optical tomographic methods is discussed. Finally, potential NIR applications such as in-vivo adaptive neural photostimulation and cancer targeting are discussed.

Citation Download Citation

Jeremy Kress and Kambiz Pourrezaei "Adaptive focus for deep tissue using diffuse backscatter", Proc. SPIE 8941, Optical Interactions with Tissue and Cells XXV; and Terahertz for Biomedical Applications, 89410P (26 February 2014); https://doi.org/10.1117/12.2032525

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KEYWORDS

Digital micromirror devices

Tissues

Backscatter

Modulation

Tissue optics

Image transmission

Binary data

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