Microfluidics on liquid handling stations (µF-on-LHS): a new industry-compatible microfluidic platform

Jörg Kittelmann; Carsten P. Radtke; Ansgar Waldbaur; Christiane Neumann; Jürgen Hubbuch; Bastian E. Rapp

doi:10.1117/12.2044665

6 March 2014 Microfluidics on liquid handling stations (μF-on-LHS): a new industry-compatible microfluidic platform

Jörg Kittelmann, Carsten P. Radtke, Ansgar Waldbaur, Christiane Neumann, Jürgen Hubbuch, Bastian E. Rapp

Proceedings Volume 8976, Microfluidics, BioMEMS, and Medical Microsystems XII; 89760G (2014) https://doi.org/10.1117/12.2044665
Event: SPIE MOEMS-MEMS, 2014, San Francisco, California, United States

Abstract

Since the early days microfluidics as a scientific discipline has been an interdisciplinary research field with a wide scope of potential applications. Besides tailored assays for point-of-care (PoC) diagnostics, microfluidics has been an important tool for large-scale screening of reagents and building blocks in organic chemistry, pharmaceutics and medical engineering. Furthermore, numerous potential marketable products have been described over the years. However, especially in industrial applications, microfluidics is often considered only an alternative technology for fluid handling, a field which is industrially mostly dominated by large-scale numerically controlled fluid and liquid handling stations. Numerous noteworthy products have dominated this field in the last decade and have been inhibited the widespread application of microfluidics technology. However, automated liquid handling stations and microfluidics do not have to be considered as mutually exclusive approached. We have recently introduced a hybrid fluidic platform combining an industrially established liquid handling station and a generic microfluidic interfacing module that allows probing a microfluidic system (such as an essay or a synthesis array) using the instrumentation provided by the liquid handling station. We term this technology “Microfluidic on Liquid Handling Stations (μF-on-LHS)” – a classical “best of both worlds”- approach that allows combining the highly evolved, automated and industry-proven LHS systems with any type of microfluidic assay. In this paper we show, to the best of our knowledge, the first droplet microfluidics application on an industrial LHS using the μF-on-LHS concept.

Citation Download Citation

Jörg Kittelmann, Carsten P. Radtke, Ansgar Waldbaur, Christiane Neumann, Jürgen Hubbuch, and Bastian E. Rapp "Microfluidics on liquid handling stations (μF-on-LHS): a new industry-compatible microfluidic platform", Proc. SPIE 8976, Microfluidics, BioMEMS, and Medical Microsystems XII, 89760G (6 March 2014); https://doi.org/10.1117/12.2044665

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KEYWORDS

Microfluidics

Liquids

Connectors

Computer aided design

Manufacturing

Interfaces

Polymers

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