Optogenetic control of cortical circuits

Valentin Dragoi

doi:10.1117/12.2657789

17 March 2023 Optogenetic control of cortical circuits

Valentin Dragoi

Proceedings Volume PC12366, Optogenetics and Optical Manipulation 2023; PC1236603 (2023) https://doi.org/10.1117/12.2657789
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Our perception of the environment relies on the efficient propagation of neural signals across cortical networks. During the time course of a day, neural responses fluctuate dramatically as the state of the brain changes to possibly influence how electrical signals propagate across neural circuits. Here, we used multielectrode laminar arrays to reveal that brain state strongly modulates the propagation of neural activity across the layers of early visual cortex (V1). We optogenetically induced synchronized state transitions within a group of neurons and found that although optogenetic stimulation elicits stronger neural responses during wakefulness relative to rest, signals propagate only weakly across the cortical column during wakefulness. In contrast, the light-induced population activity vigorously propagates throughout the entire cortical column during rest even when neurons are in a desynchronized wake-like state prior to light stimulation.

Conference Presentation

Citation Download Citation

Valentin Dragoi "Optogenetic control of cortical circuits", Proc. SPIE PC12366, Optogenetics and Optical Manipulation 2023, PC1236603 (17 March 2023); https://doi.org/10.1117/12.2657789

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