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6 March 2023 Photon economy of pulse-sampling vs TCSPC fluorescence lifetime imaging
Xiangnan Zhou, Julien Bec, Laura Marcu
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Proceedings Volume PC12370, Design and Quality for Biomedical Technologies XVI; PC1237005 (2023) https://doi.org/10.1117/12.2650311
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Pulse sampling fluorescence Lifetime Imaging (PS-FLIm) is a powerful noninvasive technique with applications to basic science and translational clinical research. However, little is known about the photon-economy of PS-FLIm. We report the first study about the photon-economy of PS-FLIm. We found that for in vivo measurements, the photon rate of multispectral PS-FLIm ranges from 1 to 5 GHz (three channels), order of magnitude higher than that of TCSPC and the F-value of PS-FLIm is less performant than that of TCSPC. This study is a first step toward understanding the photon-economy of PS-FLIm and will facilitate the optimization of PS-FLIm for future clinical use.
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Xiangnan Zhou, Julien Bec, and Laura Marcu "Photon economy of pulse-sampling vs TCSPC fluorescence lifetime imaging", Proc. SPIE PC12370, Design and Quality for Biomedical Technologies XVI, PC1237005 (6 March 2023); https://doi.org/10.1117/12.2650311
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KEYWORDS
Fluorescence lifetime imaging
Photodetectors
Sensors
In vivo imaging
Luminescence
Laser systems engineering
Photonic nanostructures
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