Blood flow signatures from an ex-corpus human blood flow system for physiological control in retina-mimicking silicone phantoms

Vincent S. Zoutenbier; Arjen Amelink; Johannes F de Boer

doi:10.1117/12.2650711

6 March 2023 Blood flow signatures from an ex-corpus human blood flow system for physiological control in retina-mimicking silicone phantoms

Vincent S. Zoutenbier, Arjen Amelink, Johannes F de Boer

Author Affiliations +

Proceedings Volume PC12370, Design and Quality for Biomedical Technologies XVI; PC123700J (2023) https://doi.org/10.1117/12.2650711
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We present experimental results using ex-vivo human blood in a setup built to mimic the scattering and flow properties of retinal vasculature. This system controls sources of imaging variability to assist with extracting the core physical principles required to better understand in-vivo OCT, doppler OCT, and SLO data. The setup consists of a flow system which is able to manipulate the blood oxygenation level/flow velocity and interchangeable silicone-elastomer capillaries which acts as an optical window to the flow medium. Here, we reproduce the well-known hour-glass profile in an OCT B-scan cross-section of our phantom capillary, typically seen in small-diameter vasculature.

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Citation Download Citation

Vincent S. Zoutenbier, Arjen Amelink, and Johannes F de Boer "Blood flow signatures from an ex-corpus human blood flow system for physiological control in retina-mimicking silicone phantoms", Proc. SPIE PC12370, Design and Quality for Biomedical Technologies XVI, PC123700J (6 March 2023); https://doi.org/10.1117/12.2650711

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KEYWORDS

Blood circulation

Control systems

Silicon

Absorption

Blood

Optical coherence tomography

Capillaries

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