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17 March 2023 Deuterium probed brain lipid metabolic activities during aging processes (Conference Presentation)
Lingyan Shi, Yajuan Li, Hongje Jang, Phyllis Chang, Sahran Hussain
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Proceedings Volume PC12398, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIV; PC1239802 (2023) https://doi.org/10.1117/12.2647999
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Our current study using deuterium oxide probed stimulated Raman Scattering (DO-SRS) imaging provides new insights in brain lipid metabolism in female and male Drosophila individuals during aging processes. We found that the 3D volumetric distribution of newly synthesized lipids is heterogeneous, aged male and female flies have different metabolic activities in brain LDs, the glial LDs remain predominantly TAGs during aging, lipogenic diets improve brain functions by promoting lipid biosynthesis, and the IIS pathway mediates diets-regulated brain lipid metabolism.
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Lingyan Shi, Yajuan Li, Hongje Jang, Phyllis Chang, and Sahran Hussain "Deuterium probed brain lipid metabolic activities during aging processes (Conference Presentation)", Proc. SPIE PC12398, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIV, PC1239802 (17 March 2023); https://doi.org/10.1117/12.2647999
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KEYWORDS
Brain
Mode conditioning cables
Modulation
Organisms
Signal processing
Glia
Nerve
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