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17 March 2023 Multiplexed spatial profiling of cancer enabled by Raman imaging (Conference Presentation)
Olga Eremina, Alexander Czaja, Augusta Fernando, Cristina Zavaleta
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Proceedings Volume PC12398, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIV; PC123980D (2023) https://doi.org/10.1117/12.2650294
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Profiling the heterogeneous landscape of cell types and biomolecules is rapidly being adopted to address current imperative research questions. Precision medicine seeks advancements in molecular spatial profiling techniques with highly multiplexed imaging capabilities and sub-cellular resolution, which remains an extremely complex task. Surface-enhanced Raman spectroscopy (SERS) imaging offers new promise through the utilization of nanoparticle-based contrast agents that exhibit narrow spectral features and molecular specificity. Herein, we report the first demonstration of simultaneously multiplexing 26 different nanoparticles in a single imaging pixel with subcellular resolution.
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Olga Eremina, Alexander Czaja, Augusta Fernando, and Cristina Zavaleta "Multiplexed spatial profiling of cancer enabled by Raman imaging (Conference Presentation)", Proc. SPIE PC12398, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIV, PC123980D (17 March 2023); https://doi.org/10.1117/12.2650294
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KEYWORDS
Multiplexing
Profiling
Cancer
Surface enhanced Raman spectroscopy
Raman spectroscopy
Particles
Image resolution
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