Fast hyperspectral SRS for analysis of drug tablet formulation

Yuxiao Wei; Isaac J Pence; Conor L Evans

doi:10.1117/12.3001829

13 March 2024 Fast hyperspectral SRS for analysis of drug tablet formulation

Yuxiao Wei, Isaac J Pence, Conor L Evans

Proceedings Volume PC12821, Visualizing and Quantifying Drug Distribution in Tissue VIII; PC128210C (2024) https://doi.org/10.1117/12.3001829
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Pharmaceutical development of solid-state formulations requires testing for uniformity and stability of active pharmaceutical ingredients and excipients. Solid-state properties such as component distribution and grain size are crucial factors of dissolution profile, which greatly affect drug efficacy and toxicity, and can only be analyzed spatially by chemical imaging (CI) techniques. Current CI techniques such as near infrared and confocal Raman spectroscopy do not offer high chemical and spatial resolution at speeds feasible for integration into the pharmaceutical quality control and quality assurance processes. We demonstrate fast chemical imaging by epi-detected sparse spectral sampling stimulated Raman scattering to quantify API and excipient degradation and distribution.

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Yuxiao Wei, Isaac J Pence, and Conor L Evans "Fast hyperspectral SRS for analysis of drug tablet formulation", Proc. SPIE PC12821, Visualizing and Quantifying Drug Distribution in Tissue VIII, PC128210C (13 March 2024); https://doi.org/10.1117/12.3001829

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KEYWORDS

Raman scattering

Tablets

Microscopy

Solids

Visualization

Chemical analysis

Imaging spectroscopy

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