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Interpretation of cardiac pulsatility in cerebral blood flow measured with transcranial doppler ultrasound (TCD) plays an important role in neurocritical care. However, TCD is only sensitive to large arteries, whereas the optical technique diffuse correlation spectroscopy (DCS) can detect microvascular flow. We develop and apply analysis methods to quantify morphological features of cerebral blood flow waveforms measured with DCS. We characterize normative waveforms in healthy adults at rest and report a waveform response to an intervention known to induce vasodilation (hypercapnia). We further show changes in waveform morphology in subarachnoid hemorrhage (SAH) patients with cerebral vasospasm compared to healthy controls.
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Tara M. Urner, Kyle Cowdrick, Eashani Sathialingam, Erin M. Buckley, "Pulsatile microvascular cerebral blood flow waveforms as a biomarker of vascular health," Proc. SPIE PC12376, Optical Tomography and Spectroscopy of Tissue XV, PC123760H (7 March 2023); https://doi.org/10.1117/12.2650455