Presentation
17 March 2023 Near infrared imaging and detection of pathogens with multiplexed nanosensors (Conference Presentation)
Sebastian Kruss
Author Affiliations +
Abstract
Infectious diseases are a major problem for both human as well as plant health. Fast and specific detection is needed to combat these diseases. We developed near infrared (NIR) fluorescent nanosensors and used them for fingerprinting of clinically important bacteria and pathogen responses in plants. They are based on single-walled carbon nanotubes (SWCNTs) that fluoresce in the NIR optical tissue transparency window. They were chemically tailored to detect metabolites as well as specific virulence factors (lipopolysaccharides, siderophores,…) and integrated into hydrogel arrays. It allowed us to detect important bacteria (Staphylococcus aureus,…) by remote (≥25 cm) NIR imaging. In another approach we developed nanosensors that change their spectral signature in response to polyphenols, which are released by plants exposed to insects and pathogens. They visualized the plant’s chemical defense remotely in the NIR, which shows the huge potential for monitoring of pathogens.
Conference Presentation
© (2023) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Sebastian Kruss "Near infrared imaging and detection of pathogens with multiplexed nanosensors (Conference Presentation)", Proc. SPIE PC12397, Frontiers in Biological Detection: From Nanosensors to Systems XV, PC1239708 (17 March 2023); https://doi.org/10.1117/12.2653804
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KEYWORDS
Near infrared

Pathogens

Nanosensors

Bacteria

Multiplexing

Sensors

Tissue optics

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