Evaluating the relationship between microfractures and perfusion during osseointegration with intraoperative dynamic contrast-enhanced fluorescence imaging

Olivia P. Jackson; Valentin V. Demidov; Jason R. Gunn; Samuel S. Streeter; Jonathan Thomas Elliott; I. Leah Gitajn

doi:10.1117/12.3003006

13 March 2024 Evaluating the relationship between microfractures and perfusion during osseointegration with intraoperative dynamic contrast-enhanced fluorescence imaging

Olivia P. Jackson, Valentin V. Demidov, Jason R. Gunn, Samuel S. Streeter, Jonathan Thomas Elliott, I. Leah Gitajn

Author Affiliations +

Proceedings Volume PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X; PC128250M (2024) https://doi.org/10.1117/12.3003006
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

In osseointegrated prosthesis surgery, implant failure is a significant complication caused by inadequate bone healing influenced by microfractures and decreased perfusion. Current perfusion assessment techniques are not capable to detect subtle damage that impacts healing. In this study, we employed dynamic contrast-enhanced fluorescent imaging (DCE-FI) to quantify changes in bone blood supply caused by osseointegration and correlated them with the extent of microfracturing at the bone-hardware interface detected with micro computed tomography. Performed experiments enable the translation of the developed technique to the second phase of the study: investigation of the optimal implant diameter relative to the inner diameter of the bone and intraoperative prediction of future implant failure after osseointegration in a longitudinal pre-clinical study.

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(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Olivia P. Jackson, Valentin V. Demidov, Jason R. Gunn, Samuel S. Streeter, Jonathan Thomas Elliott, and I. Leah Gitajn "Evaluating the relationship between microfractures and perfusion during osseointegration with intraoperative dynamic contrast-enhanced fluorescence imaging", Proc. SPIE PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X, PC128250M (13 March 2024); https://doi.org/10.1117/12.3003006

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KEYWORDS

Bone

Fluorescence imaging

Biological imaging

Perfusion imaging

Indocyanine green

Interfaces

Ionizing radiation

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