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13 March 2024 Label-free multiphoton metabolic imaging of a 3D human brain-like tissue model of Alzheimer's disease
Maria Savvidou, Adam Mullis, Yang Zhang, David Kaplan, Irene Georgakoudi
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Proceedings Volume PC12827, Multiscale Imaging and Spectroscopy V; PC128270D (2024) https://doi.org/10.1117/12.3003549
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
We aim to highlight the potential of label-free, TPEF metabolic imaging to gain unique insights in the development of Alzheimer’s disease (AD). Using an engineered brain tissue model infected with HSV-1 to induce AD phenotypes, we focus on dynamic changes associated with metabolic function, as reported by both the redox ratio and mitochondrial clustering, and the development of Aβ+ fibrillar plaque like formations (PLFs).
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Maria Savvidou, Adam Mullis, Yang Zhang, David Kaplan, and Irene Georgakoudi "Label-free multiphoton metabolic imaging of a 3D human brain-like tissue model of Alzheimer's disease", Proc. SPIE PC12827, Multiscale Imaging and Spectroscopy V, PC128270D (13 March 2024); https://doi.org/10.1117/12.3003549
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KEYWORDS
3D modeling
3D image processing
Alzheimer disease
Brain tissue
Mitochondria
Stereoscopy
Nervous system
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