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10 May 2024 An on-demand bioresorbable triboelectric neurostimulator
Dong-Min Lee, Sang-Woo Kim
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Proceedings Volume PC12948, Soft Mechatronics and Wearable Systems; PC129480N (2024) https://doi.org/10.1117/12.3014494
Event: SPIE Smart Structures + Nondestructive Evaluation, 2024, Long Beach, California, United States
Abstract
Bioresorbable bioelectronics, with their natural degradation properties, hold significant potential to eliminate the need for surgical removal. Despite notable achievements, two major challenges hinder their practical application in medical settings. Firstly, they necessitate sustainable energy solutions with biodegradable components via biosafe powering mechanisms. More importantly, reliability in their function is undermined by unpredictable device lifetimes due to the complex polymer degradation kinetics. Here, we propose an on-demand bioresorbable neurostimulator to address these issues, thus allowing for clinical operations to be manipulated using biosafe ultrasound sources. Our ultrasound-mediated transient mechanism enables i) electrical stimulation through transcutaneous ultrasound-driven triboelectricity and ii) rapid device elimination using high-intensity ultrasound without adverse health effects. Furthermore, we perform neurophysiological analyses to show that our neurostimulator provides therapeutic benefits for both compression peripheral nerve injury and hereditary peripheral neuropathy.
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Dong-Min Lee and Sang-Woo Kim "An on-demand bioresorbable triboelectric neurostimulator", Proc. SPIE PC12948, Soft Mechatronics and Wearable Systems, PC129480N (10 May 2024); https://doi.org/10.1117/12.3014494
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KEYWORDS
Nerve
Surgery
Electrodes
Injuries
Nervous system
Magnesium
Neurological disorders
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