Blue light Exposure And Long-Term Deficits In Visual Function

A. M. Clarke

doi:10.1117/12.958787

7 October 1980 Blue light Exposure And Long-Term Deficits In Visual Function

A. M. Clarke

Proceedings Volume 0229, Ocular Effects of Non-Ionizing Radiation; (1980) https://doi.org/10.1117/12.958787
Event: 1980 Technical Symposium East, 1980, Washington, D.C., United States

Abstract

During the last 6 months of 1976, the fovea of two trained rhesus monkeys were exposed to a 10 nm bandwidth source, centered at 441 nm, at energy levels representing up to three times that required in the paramacula to cause minimal, ophthalmoscopically visible lesions to appear 48 hours postexposure (30 J/cm² to 90 J/cm², 1000 sec). After the acute period, a visual decrement lasting beyond 30 days postexposure occurred only for the 90 J/cm², 1000 second fovea' exposure; the statistically significant criteria for recognition of the 20/20 (1.0 min of arc) Landolt ring target was not met, although the criteria for the 20/30 (1.5 min of arc) target was continuously met after 33 days of recovery. The animals are still regularly tested in the original protocol for visual acuity, and additionally have been examined for spectral sensitivity and changes in reaction time to the visual stimulus. During the last 6 months of 1979, only the eye originally exposed at the 90 J/cm² level failed at any test session to meet the recognition criteria for 1.0 min targets, and all eyes met the criteria for 1.5 min targets at every session. This indicates no long-term changes in the visual acuity, ruling out physiologic repair mechanisms operating beyond the first 30 to 60 days postexposure, or long term degenerative changes accumulating after the initial recovery period. Additionally, the spectral sensitivity of the subject exposed to higher levels shows a mild red but no blue deficit for 20/50 (2.5 min) targets compared to the CIE photopic function. At 1.5 min however, the spectral sensitivity would seem to be better fit by a single photopigment curve, centered at 535 nm.

Citation Download Citation

A. M. Clarke "Blue light Exposure And Long-Term Deficits In Visual Function", Proc. SPIE 0229, Ocular Effects of Non-Ionizing Radiation, (7 October 1980); https://doi.org/10.1117/12.958787

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