Seed mediated one-pot growth of versatile heterogeneous upconversion nanocrystals for multimodal bioimaging

Shihui Wen; Du Li; Deming Liu; Xiaoxue Xu; Yi Du; David R. G. Mitchell; Bingyang Shi; Xiangyang Shi; Dayong Jin

doi:10.1117/12.2245172

9 December 2016 Seed mediated one-pot growth of versatile heterogeneous upconversion nanocrystals for multimodal bioimaging

Shihui Wen, Du Li, Deming Liu, Xiaoxue Xu, Yi Du, David R. G. Mitchell, Bingyang Shi, Xiangyang Shi, Dayong Jin

Author Affiliations +

Proceedings Volume 10013, SPIE BioPhotonics Australasia; 1001315 (2016) https://doi.org/10.1117/12.2245172
Event: SPIE BioPhotonics Australasia, 2016, Adelaide, Australia

Abstract

The rapid development of a variety of molecular contrast agents makes the multimodality bioimaging highly attractive towards higher resolution, more sensitive, informative diagnosis. The key lies in the development of facile material synthesis that allows the integration of multiple contrast agents, ideally in a way that each of the components should be logically assembled to maximize their performances. Here, we report the one-pot programmable growth of multifunctional heterogeneous nanocrystal with tunable size, shape, composition, and properties. We demonstrated a facile one-pot hot-injection method to enable the highly selectively controlled growth of different sodium lanthanide fluoride nanomaterials in either longitudinal or transversal directions with atomic scale precision. This technique allows the upconversion luminescence signal, MRI signal and x-ray signal logically integrated and optimized within one single versatile nanoplatform for multimode bioimaging. These findings suggest that the facile strategy developed here have the promising to get the desired heterogeneous nanocrystals as an all-in-one contrast agent for integrated and self-correlative multimodal bioimaging.

Citation Download Citation

Shihui Wen, Du Li, Deming Liu, Xiaoxue Xu, Yi Du, David R. G. Mitchell, Bingyang Shi, Xiangyang Shi, and Dayong Jin "Seed mediated one-pot growth of versatile heterogeneous upconversion nanocrystals for multimodal bioimaging", Proc. SPIE 10013, SPIE BioPhotonics Australasia, 1001315 (9 December 2016); https://doi.org/10.1117/12.2245172

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KEYWORDS

Nanocrystals

Magnetic resonance imaging

Nanorods

Computed tomography

Lanthanides

Upconversion

In vivo imaging

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