Towards noninvasive drug distribution in tissues: coherent Raman microspectroscopy of chiral molecules

Georgi I. Petrov; Vladislav V. Yakovlev

doi:10.1117/12.2252944

21 February 2017 Towards noninvasive drug distribution in tissues: coherent Raman microspectroscopy of chiral molecules

Georgi I. Petrov, Vladislav V. Yakovlev

Proceedings Volume 10046, Visualizing and Quantifying Drug Distribution in Tissue; 1004604 (2017) https://doi.org/10.1117/12.2252944
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Many biologically active molecules are chiral. Many drugs, which are currently in use, are supplied as an equimolar mixture of enantiomers. Although they have the same chemical structure, i.e. are not distinguishable by conventional Raman spectroscopy, most isomers of chiral drugs exhibit marked differences in biological activities such as pharmacology, toxicology, pharmacokinetics, metabolism, etc. In this report we introduced a new spectroscopic tool to extend nonlinear Raman spectroscopy to chiral substances.

Conference Presentation

Citation Download Citation

Georgi I. Petrov and Vladislav V. Yakovlev "Towards noninvasive drug distribution in tissues: coherent Raman microspectroscopy of chiral molecules", Proc. SPIE 10046, Visualizing and Quantifying Drug Distribution in Tissue, 1004604 (21 February 2017); https://doi.org/10.1117/12.2252944

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