Grating-based tomography applications in biomedical engineering

Georg Schulz; Peter Thalmann; Anna Khimchenko; Bert Müller

doi:10.1117/12.2274244

6 October 2017 Grating-based tomography applications in biomedical engineering

Georg Schulz, Peter Thalmann, Anna Khimchenko, Bert Müller

Proceedings Volume 10391, Developments in X-Ray Tomography XI; 1039117 (2017) https://doi.org/10.1117/12.2274244
Event: SPIE Optical Engineering + Applications, 2017, San Diego, California, United States

Abstract

For the investigation of soft tissues or tissues consisting of soft and hard tissues on the microscopic level, hard X-ray phase tomography has become one of the most suitable imaging techniques. Besides other phase contrast methods grating interferometry has the advantage of higher sensitivity than inline methods and the quantitative results. One disadvantage of the conventional double-grating setup (XDGI) compared to inline methods is the limitation of the spatial resolution. This limitation can be overcome by removing the analyser grating resulting in a single-grating setup (XSGI). In order to verify the performance of XSGI concerning contrast and spatial resolution, a quantitative comparison of XSGI and XDGI tomograms of a human nerve was performed. Both techniques provide sufficient contrast to allow for the distinction of tissue types. The spatial resolution of the two-fold binned XSGI data set is improved by a factor of two in comparison to XDGI which underlies its performance in tomography of soft tissues. Another application for grating-based X-ray phase tomography is the simultaneous visualization of soft and hard tissues of a plaque-containing coronary artery. The simultaneous visualization of both tissues is important for the segmentation of the lumen. The segmented data can be used for flow simulations in order to obtain information about the three-dimensional wall shear stress distribution needed for the optimization of mechano-sensitive nanocontainers used for drug delivery.

Citation Download Citation

Georg Schulz, Peter Thalmann, Anna Khimchenko, and Bert Müller "Grating-based tomography applications in biomedical engineering", Proc. SPIE 10391, Developments in X-Ray Tomography XI, 1039117 (6 October 2017); https://doi.org/10.1117/12.2274244

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