Light propagation analysis in nervous tissue for wireless optogenetic nanonetworks

Stefanus Wirdatmadja; Pedram Johari; Sasitharan Balasubramaniam; Yongho Bae; Michal K. Stachowiak; Josep M. Jornet

doi:10.1117/12.2288786

14 February 2018 Light propagation analysis in nervous tissue for wireless optogenetic nanonetworks

Stefanus Wirdatmadja, Pedram Johari, Sasitharan Balasubramaniam, Yongho Bae, Michal K. Stachowiak, Josep M. Jornet

Proceedings Volume 10482, Optogenetics and Optical Manipulation 2018; 104820R (2018) https://doi.org/10.1117/12.2288786
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

In recent years, numerous methods have been sought for developing novel solutions to counter neurodegenerative diseases. An objective that is being investigated by researchers is to develop cortical implants that are able to wirelessly stimulate neurons at the single cell level. This is a major development compared to current solutions that use electrodes, which are only able to target a population of neurons, or optogenetics, which requires optical fiber-leads to be embedded deep into the brain. In this direction, the concept of wireless optogenetic nanonetworks has been recently introduced. In such architecture, miniature devices are implanted in the cortex for neuronal stimulation through optogenetics. One of the aspects that will determine the topology and performance of wireless optogenetic nanonetworks is related to light propagation in genetically-engineered neurons. In this paper, a channel model that captures the peculiarities of light propagation in neurons is developed. First, the light propagation behavior using the modified Beer-Lambert law is analyzed based on the photon transport through the nervous tissue. This includes analyzing the scattering light diffraction and diffusive reflection that results from the absorption of neural cell chromophores, as well as validating the results by means of extensive multiphysics simulations. Then, analysis is conducted on the path loss through cells at different layers of the cortex by taking into account the multi-path phenomenon. Results show that there is a light focusing effect in the soma of neurons that can potentially help the to stimulate the target cells.

Conference Presentation

Citation Download Citation

Stefanus Wirdatmadja, Pedram Johari, Sasitharan Balasubramaniam, Yongho Bae, Michal K. Stachowiak, and Josep M. Jornet "Light propagation analysis in nervous tissue for wireless optogenetic nanonetworks", Proc. SPIE 10482, Optogenetics and Optical Manipulation 2018, 104820R (14 February 2018); https://doi.org/10.1117/12.2288786

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available