Biomedical and sensing applications of a multi-mode biodegradable phosphate-based optical fiber

Ondřej Podrazky; Pavel Peterka; Soňa Vytykáčová; Jana Proboštová; Martin Kuneš; Oleksiy Lyutakov; Edoardo Ceci-Ginistrelli; Diego Pugliese; Nadia G. Boetti; Davide Janner; Daniel Milanese

doi:10.1117/12.2285148

13 February 2018 Biomedical and sensing applications of a multi-mode biodegradable phosphate-based optical fiber

Ondřej Podrazky, Pavel Peterka, Soňa Vytykáčová, Jana Proboštová, Martin Kuneš, Oleksiy Lyutakov, Edoardo Ceci-Ginistrelli, Diego Pugliese, Nadia G. Boetti, Davide Janner, Daniel Milanese

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Proceedings Volume 10488, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII; 104880H (2018) https://doi.org/10.1117/12.2285148
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

We report on the employment of a biodegradable phosphate-based optical fiber as a pH sensing probe in physiological environment. The phosphate-based optical fiber preform was fabricated by the rod-in-tube technique. The fiber biodegradability was first tested in-vitro and then its biodegradability and toxicity were tested in-vivo. Optical probes for pH sensing were prepared by the immobilization of a fluorescent dye on the fiber tip by a sol-gel method. The fluorescence response of the pH-sensor was measured as a ratio of the emission intensities at the excitation wavelengths of 405 and 450 nm.

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Ondřej Podrazky, Pavel Peterka, Soňa Vytykáčová, Jana Proboštová, Martin Kuneš, Oleksiy Lyutakov, Edoardo Ceci-Ginistrelli, Diego Pugliese, Nadia G. Boetti, Davide Janner, and Daniel Milanese "Biomedical and sensing applications of a multi-mode biodegradable phosphate-based optical fiber", Proc. SPIE 10488, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII, 104880H (13 February 2018); https://doi.org/10.1117/12.2285148

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