SRS-sensor 13C/12C  isotops measurements for detecting Helicobacter Pylori

Aleksandr Grishkanich; Yan Chubchenko; Valentin Elizarov; Aleksandr Zhevlakov; Leonid Konopelko

doi:10.1117/12.2295927

14 February 2018 SRS-sensor 13C/12C isotops measurements for detecting Helicobacter Pylori

Aleksandr Grishkanich, Yan Chubchenko , Valentin Elizarov, Aleksandr Zhevlakov, Leonid Konopelko

Proceedings Volume 10488, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII; 104881A (2018) https://doi.org/10.1117/12.2295927
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

We developed SRS-sensor 13C/12C isotops measurements detecting Helicobacter Pylori for medical diagnostics of human health. Measuring of absolute 13С/12С isotope amount ratios allows to explore the topical problems of the modern world, alcoholic beverages and tobacco, medical diagnostics of human health. SRS method is used to measure the ratio of carbon isotopes in the exhaled carbon dioxide, which is used to diagnose the human infection of Helicobacter pylori and the influence of the Helicobacter pylori bacterium on the occurrence of gastritis, gastric and duodenal ulcers. A method for the analysis of human infection with Helicobacter pylori was developed on the basis of measurements of the ratio of 13C / 12C carbon isotopes in human exhaled air with a high level of measurement accuracy. The article reviews the work in the field of provision comparability of absolute 13С/12С isotope amount ratios in the environment and food. The analysis of the technical and metrological characteristics of traditional and perspective instruments for measuring isotope ratios is presented. The provision of comparability of absolute 13С/12С isotope amount ratios is carried by gravimetrically prepared reference standards. The key features and emerging issues are discussed.

Citation Download Citation

Aleksandr Grishkanich, Yan Chubchenko , Valentin Elizarov, Aleksandr Zhevlakov, and Leonid Konopelko "SRS-sensor 13C/12C isotops measurements for detecting Helicobacter Pylori", Proc. SPIE 10488, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII, 104881A (14 February 2018); https://doi.org/10.1117/12.2295927

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