High spatial resolution x-ray luminescence computed tomography and x-ray fluorescence computed tomography

Xianjin Dai; Kathyayini Sivasubramanian; Lei Xing

doi:10.1117/12.2511875

7 March 2019 High spatial resolution x-ray luminescence computed tomography and x-ray fluorescence computed tomography

Xianjin Dai, Kathyayini Sivasubramanian, Lei Xing

Proceedings Volume 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V; 1086218 (2019) https://doi.org/10.1117/12.2511875
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

X-ray luminescence computed tomography (XLCT) and X-ray fluorescence computed tomography (XFCT) are two emerging technologies in X-ray imaging. In these modalities, images are formed through detection of secondary emissions (light in XLCT, or secondary X-rays in XFCT) following X-ray excitations. XLCT and XFCT enable us to leverage the widely used X-ray imaging for simultaneous in vivo molecular and functional imaging. Depending on the geometry of the excitation X-ray beam (pencil-, fan-, and cone-beam or coded apertures), optimal tradeoff between imaging efficiency and spatial resolution can be achieved. The novel imaging principles of XLCT/XFCT make it possible to achieve a spatial resolution comparable to that of anatomical X-ray imaging. Here, we summarize our studies in this area in the past decade and discuss their prospects.

Conference Presentation

Citation Download Citation

Xianjin Dai, Kathyayini Sivasubramanian, and Lei Xing "High spatial resolution x-ray luminescence computed tomography and x-ray fluorescence computed tomography", Proc. SPIE 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V, 1086218 (7 March 2019); https://doi.org/10.1117/12.2511875

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