Evaluation of metastatic potential of circulating tumor cells using quantitative phase imaging (QPI)

Irina Vasilenko; Vladislav Metelin; Ziver Kardasheva; Andrey Balkanov; Roman Lifenko

doi:10.1117/12.2510383

4 March 2019 Evaluation of metastatic potential of circulating tumor cells using quantitative phase imaging (QPI)

Irina Vasilenko, Vladislav Metelin, Ziver Kardasheva, Andrey Balkanov, Roman Lifenko

Proceedings Volume 10887, Quantitative Phase Imaging V; 1088724 (2019) https://doi.org/10.1117/12.2510383
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Revealing and characterization of circulating tumor cells (CTCs) is one of the most actively investigated field of oncology. It was established by the past time studies that some of these cells were in condition of apoptosis and so couldn’t initiate formation of a clinically significant metastasis. The novel opportunities associated with development of computer technologies and interferential microscopes facilitate the solution of many medico-biological problems. One of them is a method of determination of CTCs functional condition based on the phase-interferential characteristics of their nuclear structures which reflect cellular metabolic and proliferative activity and are the markers of their malignant transformation.

The analysis was carried out of the morphodensitometric biomarkers of the metastatic activity of circulating tumorous cells including conformational alterations of their nuclear structures. The reference collection of phase images of metastatic cells was created as well as the data of the morphodensitometric parameters of their metabolic activity was received.

A new information was received about heterogeneity of the circulating tumorous cells with different metastatic activity which allows the broadening of fundamental scientific knowledge concerning cancerogenesis, individualization of the observation and treatment of patients, improvement of the quality of treatment, and optimization of its cost.

Citation Download Citation

Irina Vasilenko, Vladislav Metelin, Ziver Kardasheva, Andrey Balkanov, and Roman Lifenko "Evaluation of metastatic potential of circulating tumor cells using quantitative phase imaging (QPI)", Proc. SPIE 10887, Quantitative Phase Imaging V, 1088724 (4 March 2019); https://doi.org/10.1117/12.2510383

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