The structures of neuroretinal cells are fundamentally important for their functions. Therefore, elastic light scattering spectroscopy (ELSS) is an attractive approach to characterize the structural properties of retina, particularly due to its superb structural sensitivities down to several tens of nanometers. However, ELSS in living human retina is largely unexplored due to the lack of imaging tools. Here, enabled by visible and near infrared optical coherence tomography (vnOCT), we provided a quantitative measurement of ELSS in several interested anotomical layers in living human retina. Their biophysical implications will be discussed. In addition, vnOCT provided capillary oximetry in human retina, another important measurement in understanding retinal biophysics and pathology.
|