Cervical cancer diagnostics with a multispectral Mueller polarimetric colposcope

Junha Park; Arvid Lindberg; Jeremy Vizet; Jean Rehbinder; Camille Gennet; Jean-Charles Vanel; André Nazac; Elodie Debras; Perrine Capmas; Hervé Fernandez; Angelo Pierangelo

doi:10.1117/12.2526934

19 July 2019 Cervical cancer diagnostics with a multispectral Mueller polarimetric colposcope

Junha Park, Arvid Lindberg, Jeremy Vizet, Jean Rehbinder, Camille Gennet, Jean-Charles Vanel, André Nazac, Elodie Debras, Perrine Capmas, Hervé Fernandez, Angelo Pierangelo

Author Affiliations +

Proceedings Volume 11073, Clinical and Preclinical Optical Diagnostics II; 110730A (2019) https://doi.org/10.1117/12.2526934
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Mueller polarimetric imaging appeared to be very promising to detect the modifications in the microstructure of the uterine cervix due to the development of a precancerous lesion, thus providing very useful information for diagnostics to which practitioner cannot to access with classic color imaging. The first multispectral Mueller Polarimetric Colposcope (MPC) for the in vivo analysis of the uterine cervix will be presented. It has been obtained by miniaturizing a Mueller polarimetric imaging system and “grafting” it on a conventional colposcope, which is a low magnification binocular system, currently used in medical practice to examine the uterine cervix for detection of precancerous lesions. The multispectral MPC enables to obtain reliable Mueller polarimetric images in less than 2 seconds with a spatial resolution of 100 μm simultaneously at 450, 550 and 650 nm. Currently, it is being tested in vivo in the University Hospital of Kremlin Bicêtre in France. In order to evaluate the performance of the technique, polarimetric images need to be compared with histological analyses of biopsies. The procedure developed in collaboration with medical doctors to obtain an accurate correlation between polarimetric images and biopsies will be described.

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Junha Park, Arvid Lindberg, Jeremy Vizet, Jean Rehbinder, Camille Gennet, Jean-Charles Vanel, André Nazac, Elodie Debras, Perrine Capmas, Hervé Fernandez, and Angelo Pierangelo "Cervical cancer diagnostics with a multispectral Mueller polarimetric colposcope", Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II, 110730A (19 July 2019); https://doi.org/10.1117/12.2526934

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KEYWORDS

Polarimetry

Biopsy

In vivo imaging

Polarization

Cervix

Cervical cancer

Diagnostics

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