TD-fNIRS for diagnosing glaucoma: a clinical pilot study

R. Re; D. Messenio; L. Spinelli; I. Pirovano; D. Contini; R. Colombo; R. Cubeddu; A. Torricelli

doi:10.1117/12.2526961

11 July 2019 TD-fNIRS for diagnosing glaucoma: a clinical pilot study

R. Re, D. Messenio, L. Spinelli, I. Pirovano, D. Contini, R. Colombo, R. Cubeddu, A. Torricelli

Proceedings Volume 11074, Diffuse Optical Spectroscopy and Imaging VII; 110741K (2019) https://doi.org/10.1117/12.2526961
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Glaucoma is a multifactorial optic neuropathy characterized by progressive loss of retinal ganglion cells, changes in optic disk morphology and visual field defects; its pathophysiology is still unclear. Recently it was demonstrated that glaucoma can be associated with a degenerative effect at the level of the optic nerve and the primary visual cortex. Functional near infrared spectroscopy (fNIRS) is a non-invasive optical technique, which allows the brain hemodynamic monitoring. In particular, the Time Domain fNIRS (TD-fNIRS) allows to remove from the detected signal the contribution coming from the surface (scalp, skull and cerebral fluid) in order to obtain the brain hemodynamic activation. The aim of this preliminary study is to understand if in the glaucomatous patients, the visual cortex activation during a visual stimulus is different from the one of a control group. A total of 20 subjects took part to the study. We divided them into three groups: 7 controls, 5 ocular hypertension (HYPER), and 8 glaucoma. The hemodynamic time courses of oxy- (OHB) and deoxy- (HHB) hemoglobin were compared with a hemodynamic response function (HRF) with the adaptive HRF approach. Finally, an inference test was applied (t-student) to statistically determine the visual cortex activation (simultaneous increase in OHB and decrease in HHB). The p-value threshold was set at 0.05. The 86% of the controls and the 80% of the HYPER combinations are activated; while the 81% of the glaucoma ones are not, outlining a well-defined trend. Also the OHB and HHB show drastic differences between controls and patients.

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R. Re, D. Messenio, L. Spinelli, I. Pirovano, D. Contini, R. Colombo, R. Cubeddu, and A. Torricelli "TD-fNIRS for diagnosing glaucoma: a clinical pilot study", Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 110741K (11 July 2019); https://doi.org/10.1117/12.2526961

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KEYWORDS

Visualization

Hemodynamics

Signal detection

Visual cortex

Eye

Brain

Optic nerve

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