Phase-decorrelation OCT for detection of corneal softening in an enzymatic ex vivo model of ectasia (Conference Presentation)

Brecken J. Blackburn; John P. Murray; Matthew R. Ford; Michael W. Jenkins; William J. Dupps Jr.; Andrew M. Rollins

doi:10.1117/12.2546557

9 March 2020 Phase-decorrelation OCT for detection of corneal softening in an enzymatic ex vivo model of ectasia (Conference Presentation)

Brecken J. Blackburn, John P. Murray, Matthew R. Ford, Michael W. Jenkins, William J. Dupps Jr., Andrew M. Rollins

Author Affiliations +

Proceedings Volume 11218, Ophthalmic Technologies XXX; 112180W (2020) https://doi.org/10.1117/12.2546557
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Nearly all benchtop studies of corneal biomechanics have relied on protocols which stiffen the cornea, such as riboflavin-UV crosslinking, as a way of providing contrast and validation of biomechanical measurements. However, there are strong clinical motivations to detect softening of the cornea. In this work, we present the evidence that phase-decorrelation OCT (PhD-OCT) is able to detect a small degree of corneal softening due to enzymatic digestion. This benchtop study supports the idea that PhD-OCT may detect keratoconus and early ectasia clinically.

Conference Presentation

Citation Download Citation

Brecken J. Blackburn, John P. Murray, Matthew R. Ford, Michael W. Jenkins, William J. Dupps Jr., and Andrew M. Rollins "Phase-decorrelation OCT for detection of corneal softening in an enzymatic ex vivo model of ectasia (Conference Presentation)", Proc. SPIE 11218, Ophthalmic Technologies XXX, 112180W (9 March 2020); https://doi.org/10.1117/12.2546557

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