Investigating the functional response of human cones and rods with a combined adaptive optics SLO-OCT system

Mehdi Azimipour; Denise Valente; Kari V. Vienola; John S. Werner; Robert J. Zawadzki; Ravi S. Jonnal

doi:10.1117/12.2544462

19 February 2020 Investigating the functional response of human cones and rods with a combined adaptive optics SLO-OCT system

Mehdi Azimipour, Denise Valente, Kari V. Vienola, John S. Werner, Robert J. Zawadzki, Ravi S. Jonnal

Author Affiliations +

Proceedings Volume 11218, Ophthalmic Technologies XXX; 1121813 (2020) https://doi.org/10.1117/12.2544462
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

In vivo functional imaging of human photoreceptors is an emerging field, with compelling potential applications in basic science, translational research, and clinical management of ophthalmic disease. Measurement of light-evoked changes in the cone photoreceptors has been successfully demonstrated using adaptive optics (AO) coherent flood illumination (CFI), AO scanning light ophthalmoscopy (SLO), AO optical coherence tomography (OCT), and full-field OCT with digital aberration correction (DAC). While the optical and computational principles of these systems differ greatly, and while these differences manifest in the resulting measurements, we believe that the approaches are all sensitive to light-evoked swelling of the cells. We describe a combined OCT-SLO with AO designed to measure this light-evoked swelling. In addition to OCT measurement of cone responses, we report their simultaneous OCT-SLO measurement as well as OCT measurement of rod photoreceptor function, neither of which, to our knowledge, have been reported before.

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Citation Download Citation

Mehdi Azimipour, Denise Valente, Kari V. Vienola, John S. Werner, Robert J. Zawadzki, and Ravi S. Jonnal "Investigating the functional response of human cones and rods with a combined adaptive optics SLO-OCT system", Proc. SPIE 11218, Ophthalmic Technologies XXX, 1121813 (19 February 2020); https://doi.org/10.1117/12.2544462

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