Contact lens-based lysozyme detection in tear using a mobile and cost-effective sensor (Conference Presentation)

Zachary S. Ballard; Sarah Bazargan; Diane Jung; Shyama Sathianathan; Ashley Clemens; Daniel Shir; Saba Al-Hashimi; Aydogan Ozcan

doi:10.1117/12.2546656

9 March 2020 Contact lens-based lysozyme detection in tear using a mobile and cost-effective sensor (Conference Presentation)

Zachary S. Ballard, Sarah Bazargan, Diane Jung, Shyama Sathianathan, Ashley Clemens, Daniel Shir, Saba Al-Hashimi, Aydogan Ozcan

Author Affiliations +

Proceedings Volume 11230, Optics and Biophotonics in Low-Resource Settings VI; 112300R (2020) https://doi.org/10.1117/12.2546656
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We demonstrate a contact-lens (CL) based mobile sensing system which can be used to measure protein levels in human tear. By using a cost-effective mobile-phone-based well-plate reader and a fluorescent assay, we quantify lysozyme nonspecifically bound to CLs. We monitored the lysozyme levels of 9 healthy volunteers to establish individual baselines, and then compared these measurements to participants who had been diagnosed with Dry Eye Disease (N=6), observing a statistically significant difference in their means. Due to its non-invasive and simple operation, this method could be used for tear-based sensing and health monitoring applications in point-of-care settings and at home.

Conference Presentation

Citation Download Citation

Zachary S. Ballard, Sarah Bazargan, Diane Jung, Shyama Sathianathan, Ashley Clemens, Daniel Shir, Saba Al-Hashimi, and Aydogan Ozcan "Contact lens-based lysozyme detection in tear using a mobile and cost-effective sensor (Conference Presentation)", Proc. SPIE 11230, Optics and Biophotonics in Low-Resource Settings VI, 112300R (9 March 2020); https://doi.org/10.1117/12.2546656

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available