Characterization of nano sensitive sub-micron scale tissue-structural multifractality and its alteration in tumor progress

Nandan Das; Sergey Alexandrov; Róisín M. Dwyer; Rolf Saager; Nirmalya Ghosh; Martin Leahy

doi:10.1117/12.2555840

21 February 2020 Characterization of nano sensitive sub-micron scale tissue-structural multifractality and its alteration in tumor progress

Nandan Das, Sergey Alexandrov, Róisín M. Dwyer, Rolf Saager, Nirmalya Ghosh, Martin Leahy

Author Affiliations +

Proceedings Volume 11239, Dynamics and Fluctuations in Biomedical Photonics XVII; 1123912 (2020) https://doi.org/10.1117/12.2555840
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Assessment of disease using OCT is an actively investigated problem, owing to many unresolved challenges in early disease detection, diagnosis and treatment response monitoring. The spatial scale to which the information can be obtained from the scattered light is limited by the diffraction limit (~λ/2; λ = wavelength of light is typically in the micron level) and the axial resolution of OCT systems is limited by the inverse of spectral bandwidth. Yet, onset or progression of disease /precancer is typically associated with subtle alterations in the tissue dielectric and its ultra-structural morphology. On the other hand, biological tissue is known to have ultra-structural multifractality. For both the fundamental study of biological processes and early diagnosis of pathological processes, information on the nanoscale in the tissue sub-micron structural morphology is crucial. Therefore, we have developed a novel spectroscopic and label-free 3D OCT system with nanoscale sensitivity in combination of multifractal analysis for extraction and quantification of tissue ultra-structural multifractal parameters. This present approach demonstrated its capability to measure nano-sensitive tissue ultra-structural multifractality. In an initial study, we found that nano-sensitive sub-micron structural multifractality changes in transition from healthy to tumor in pathologically characterized fresh tissue samples. This novel method for extraction of nanosensitive tissue multifractality promises to develop a non-invasive diagnosis tool for early cancer detection.

Citation Download Citation

Nandan Das, Sergey Alexandrov, Róisín M. Dwyer, Rolf Saager, Nirmalya Ghosh, and Martin Leahy "Characterization of nano sensitive sub-micron scale tissue-structural multifractality and its alteration in tumor progress", Proc. SPIE 11239, Dynamics and Fluctuations in Biomedical Photonics XVII, 1123912 (21 February 2020); https://doi.org/10.1117/12.2555840

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